# ANIMAL MODELS OF ASTHMA AND OCCUPATIONAL LUNG DISEASE

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 1990 · $158,401

## Abstract

The program has the following goals and objectives.
1.  To maintain a colony of 3 groups of rhesus monkeys including
normal animals, animals with IgE mediated cutaneous and airway
reactivity to ascaris antigen or animals with IgE positive skin
reactivity but negative airway reactivity.  Because the antigen
airway reactors have hyperreative airways this group of allergic
rhesus monkeys may closely simulate human IgE mediated
asthma.
2.  To establish quantitative dose-response reactions to antigen
and carbocholine in antigen reactive monkeys and carbocholine
reactivity in normal monkeys.  The carbocholine reactivity will
be an index of the degree of hyperreactivity of the airway.
3.  To determine qualitative and quantitative responses to
potentially important agonists of airway reactions in selected
asthmatics and controls monkeys.  These agonists will include
leukotriene D4 (LTD4), platelet activating factor (PAF) and
histamine releasing agent (HRA) in selected asthmatic and
control monkeys for evaluation of qualitative and quantitative
individual animal responses.
4.  To study receptor antagonists against LTD4 and PAF as
inhibiting agents for these agonists and for antigen induced
asthma.  A lipoxygenase inhibitor will be studied to determine if
antigen induced asthma is diminished by pretreating with this
agent.  The airway response to HRA will be evaluated by using
antagonists against H, LTD4 and PAF.
5.  To define the pattern of bioactive mediators released into
bronchoalveolar lavage (BAL) fluid after antigen challenge and
challenge with these mediators.
6.  To develop a monkey model of toluene diisocyanate (TDI)
asthma based on our human clinical experience in man and our
experience with a canine model of TDI asthma.

## Key facts

- **NIH application ID:** 3129561
- **Project number:** 5R01AI020060-08
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **SAM.gov UEI:** KG76WYENL5K1
- **Principal Investigator:** ROY PATTERSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $158,401
- **Award type:** 5
- **Project period:** 1983-09-01 → 1992-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129561

## Citation

> US National Institutes of Health, RePORTER application 3129561, ANIMAL MODELS OF ASTHMA AND OCCUPATIONAL LUNG DISEASE (5R01AI020060-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129561. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*