# A PROSPECTIVE STUDY OF LYMPHATIC FILARIASIS IN MAN

> **NIH NIH R01** · HARVARD MEDICAL SCHOOL · 1987 · $168,793

## Abstract

The specific goals we propose are to assess qualitative and quantitative
changes in immune responses to filarial antigens from the time when
previously unexposed individuals arrive in an endemic area until they
develop clinical and/or parasitological manifestations of lymphatic
filariasis.  Methods include quantitation of circulating T cell subclasses;
functional assessment of T cells (by antigen induced in vitro proliferation
assays), and of B lymphocytes (by assays detect in vitro production of
specific antibody to B. malayi); measurement of antifilaria antibody of
different classes and isotypes as well as of circulating immune complexes;
and analysis of parasite antigens recognized during the course of filarial
infections (by Western blots with sera from donors with differing periods
of exposure).  The ultimate goal is to identify parasite antigens that
elicit immune reactions with prognostic significance that could be included
in a potential vaccine against lymphatic filariasis in man.

## Key facts

- **NIH application ID:** 3129613
- **Project number:** 5R01AI020102-05
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **SAM.gov UEI:** JDLVAVGYJQ21
- **Principal Investigator:** WILLY F PIESSENS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $168,793
- **Award type:** 5
- **Project period:** 1983-09-01 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129613

## Citation

> US National Institutes of Health, RePORTER application 3129613, A PROSPECTIVE STUDY OF LYMPHATIC FILARIASIS IN MAN (5R01AI020102-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129613. Licensed CC0.

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