# STRUCTURE/FUNCTION RELATIONSHIPS IN HUMAN MHC MOLECULES

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1991 · $100,274

## Abstract

The specific aim of this project is to employ site-directed
mutagenesis of the major human histocompatibility complex molecules
(class I and class II), the restricting elements on the antigen
presenting or target cell, in order to explore the relationship of
their structures to their functions in the immune system, as well
as to define the interaction of the class II antigen with the T
cell protein CD4. In this study we will examine primarily the class
I HLA antigen HLA-A2, and will also commence studies of the class
II HLA antigen DRl.

## Key facts

- **NIH application ID:** 3129675
- **Project number:** 5R01AI020182-07
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** JACK L STROMINGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $100,274
- **Award type:** 5
- **Project period:** 1988-04-01 → 1993-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129675

## Citation

> US National Institutes of Health, RePORTER application 3129675, STRUCTURE/FUNCTION RELATIONSHIPS IN HUMAN MHC MOLECULES (5R01AI020182-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129675. Licensed CC0.

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