# ADAPTATION TO ANTIBIOTIC RESISTANCE IN MUCOR

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA-IRVINE · 1988 · $114,829

## Abstract

The purpose of this research is to investigate the adaptive antibiotic
resistance of the fungus Mucor.  Although initially sensitive to the
cycloheximide, trichodermin, and amphotericin B, Mucor will "adapt" to
these antibiotics after several hours.  This adaptation involves all the
cells in the population, and does not result in the destruction of the
inhibitors.  Data show that adapted cells will modify C14-trichodermin,
presumably producing inactive forms.  This antibiotic adaptation will be
investigated by studying:  (1) mechanisms for the modification of
antibiotics by adapted cells, and (2) subsidiary mechanisms, including the
transport and sequestering of the drugs.  These studies will be facilitated
by the availability of mutants with altered responses to the three
antibiotics.  These mutants fall into two classes:  constitutively
resistant to antibiotics and super sensitive (i.e., no adaptive response).

## Key facts

- **NIH application ID:** 3129761
- **Project number:** 5R01AI020238-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **SAM.gov UEI:** MJC5FCYQTPE6
- **Principal Investigator:** PAUL S SYPHERD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $114,829
- **Award type:** 5
- **Project period:** 1985-09-30 → 1990-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129761

## Citation

> US National Institutes of Health, RePORTER application 3129761, ADAPTATION TO ANTIBIOTIC RESISTANCE IN MUCOR (5R01AI020238-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129761. Licensed CC0.

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