# IMMUNOLOGY OF MHC RESTRICTION OF T CELLS

> **NIH NIH R01** · HARVARD MEDICAL SCHOOL · 1987 · $256,541

## Abstract

The study of MHC restriction of T cell specificity and more particularly
the relationship of this phenomenon to Ir gene function, has been a major
concern of our laboratory.  This project addresses three aspects of the
specificity of T lymphocytes restricted to react with antigen and self Ia
molecules.  1. The nature of Ia-antigen interactions, and the specificity
of T cell receptors for self Ia.  2. The control of IL-1 production at the
level of the antigen presenting cells and the role of Ia molecules in this
process.  3. The selection of a differentiating T cell population in the
thymus restricted to react specifically with self Ia molecules.

## Key facts

- **NIH application ID:** 3129795
- **Project number:** 5R01AI020248-05
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **SAM.gov UEI:** JDLVAVGYJQ21
- **Principal Investigator:** BARUJ BENACERRAF
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $256,541
- **Award type:** 5
- **Project period:** 1983-08-01 → 1988-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129795

## Citation

> US National Institutes of Health, RePORTER application 3129795, IMMUNOLOGY OF MHC RESTRICTION OF T CELLS (5R01AI020248-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129795. Licensed CC0.

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