# IMMUNOBIOLOGY OF MHC RESTRICTION OF T CELLS

> **NIH NIH R01** · HARVARD MEDICAL SCHOOL · 1989 · $181,128

## Abstract

The study of antigen-specific, MHC restricted T cell interactions
has been a major focus of our laboratory.  This project addresses
three aspects of MHC restricted antigen-presentation to T
lymphocytes.

1.  The nature of processed antigens and their membrane display
on antigen-presenting cells.

2.  The manipulation of antigens and antigen-presentation to
increase immunogenicity.

3.  The role of non-MHC encoded structures in antigen-
presentation and cell-cell interaction.

These issues will be investigated with defined antigens both in
vivo and in vitro, the latter with transformed clones of functional
specific T cells in conjunction with cloned antigen-presenting
cells and model membranes.

## Key facts

- **NIH application ID:** 3129796
- **Project number:** 5R01AI020248-07
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **SAM.gov UEI:** JDLVAVGYJQ21
- **Principal Investigator:** KENNETH L ROCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $181,128
- **Award type:** 5
- **Project period:** 1983-08-01 → 1990-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129796

## Citation

> US National Institutes of Health, RePORTER application 3129796, IMMUNOBIOLOGY OF MHC RESTRICTION OF T CELLS (5R01AI020248-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129796. Licensed CC0.

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