# XLR GENE STRUCTURE AND FUNCTION

> **NIH NIH R01** · STANFORD UNIVERSITY · 1989 · $163,972

## Abstract

We wish to pursue our characterization of the newly discovered XLR
(X-chromosomal, lymphocyte regulated) gene family with respect to its
pattern of expression in B and T cells, the number of active genes, their
chromosomal organization and the location of the protein products in the
cell.  These data should provide important clues as to the function(s) of
this family of sequences and would help to determine the course of future
experimentation.  Other experiments to determine the function of XLR gene
products involve introducing XLR carrying vectors into B cell tumors at
various stages of differentiation to determine the influence of either
positive (sense-strand) or negative (anti-sense strand) expression.
Alternatively, we may try protein or anti-XLR antibody injection via red
cell ghosts.  In addition, we will try to determine the structural linkage
between this locus and the xid defect of the CBA/N mouse by restriction
fragment length polymorphism analysis (RFLP's) and the introduction of
portions of the XLR locus into mouse embryos carrying the xid defect.
These and alternative strategies should be helpful in determining the
precise defect in XLR which causes the xid phenotype.  Understanding the
molecular basis of the xid mutation may provide insights into the nature of
the late stage B cell differentiation and the postulated two subsets
thought to constitute the immunoglobulin producing response.

We will also sequence and develop antisera against the recently isolated
human equivalent of XLR and determine whether any of the inherited X-linked
immunodeficiency disorders appears to be aberrant in this gene family.  Any
such linkage between XLR and these defects would provide the first
structural basis for a human X-linked immunodeficiency as well as important
additional clues as to the genetics of this locus.

## Key facts

- **NIH application ID:** 3129897
- **Project number:** 5R01AI020320-07
- **Recipient organization:** STANFORD UNIVERSITY
- **SAM.gov UEI:** HJD6G4D6TJY5
- **Principal Investigator:** Mark Morris Davis
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $163,972
- **Award type:** 5
- **Project period:** 1983-08-01 → 1991-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3129897

## Citation

> US National Institutes of Health, RePORTER application 3129897, XLR GENE STRUCTURE AND FUNCTION (5R01AI020320-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3129897. Licensed CC0.

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