# ENDOTHELIUM-DEPENDENT RESPONSES AND FILARIASIS

> **NIH NIH R01** · MICHIGAN STATE UNIVERSITY · 1993 · $132,875

## Abstract

The overall objective of our research on skeletal muscle blood
flow is identification of the mechanisms responsible for
vasodilation associated with exercise.  The major focus of this
application is the role of endothelial cells in mediating the
vasodilation of distributing arteries which are responsible for
maintaining the pressure head to the microcirculation during
exercise.  We are also interested in the role of endothelial cells in
the dilation and development of collateral vessels which supply
the microcirculation when distributing arteries are occluded.  We
propose to elucidate the physiologic importance of endothelial
cells in mediating the vasodilation of distributing arteries.  Our
goals are (a) to determine the physiologic role of distributing
artery flow-dependent dilation in exercise hyperemia, (b) to
further characterize the mechanism of flow-dependent dilation in
the canine femoral artery, and (c) to determine the role of
endothelial cells in the dilation and growth of collateral vessels
during acute and chronic occlusion of the distributing artery.  We
will also examine the effect of heartworm (Dirofilaria immitis), a
common filarial parasitic infection of domestic dogs, on
endothelium-dependent vasodilation.

## Key facts

- **NIH application ID:** 3150178
- **Project number:** 9R01AI035757-14
- **Recipient organization:** MICHIGAN STATE UNIVERSITY
- **SAM.gov UEI:** R28EKN92ZTZ9
- **Principal Investigator:** LANA KAISER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $132,875
- **Award type:** 9
- **Project period:** 1980-04-01 → 1996-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3150178

## Citation

> US National Institutes of Health, RePORTER application 3150178, ENDOTHELIUM-DEPENDENT RESPONSES AND FILARIASIS (9R01AI035757-14). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3150178. Licensed CC0.

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