# STRUCTURE OF IMMUNOGLOBULINS AND RELATED PROTEINS

> **NIH NIH R01** · NEW YORK UNIVERSITY · 1987 · $277,372

## Abstract

The studies described in this proposal are designed to further our
understanding of the structure and function of antibody molecules, the
relationship of immune complexes to human disease and the characterization
of the major protein constituents of amyloid.  The experiments dealing with
antibody molecules and immunoglobulin variants produced by normal
individuals as well as those with multiple myeloma and related plasma cell
neoplasms are expected to shed insight into the genetic control of
immunoglobulin structure and synthesis, to define the antibody combining
sites and the expression of novel immunoglubulin genes.  We wish to
determine the factors involved in the production of rheumatoid factor
cryoglobulins which result in an immune complex type of nephritis and
vasculitis.  Finally, we are attempting to classify from a clinical,
immunohistologic and biochemical point of view a heterogeneous group of
diseases characterized by the deposition of amyloid fibrils.  Our approach
is based on the theory that all types of amyloidosis occur in individuals
who are genetically or otherwise defective in processing a soluble
precursor which is a normal serum component.

## Key facts

- **NIH application ID:** 3154648
- **Project number:** 5R01AR002594-30
- **Recipient organization:** NEW YORK UNIVERSITY
- **SAM.gov UEI:** NX9PXMKW5KW8
- **Principal Investigator:** BLAS FRANGIONE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $277,372
- **Award type:** 5
- **Project period:** 1978-09-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154648

## Citation

> US National Institutes of Health, RePORTER application 3154648, STRUCTURE OF IMMUNOGLOBULINS AND RELATED PROTEINS (5R01AR002594-30). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154648. Licensed CC0.

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