# LONGITUDINAL STUDY OF A PRE-OSTEOPOROSIS POPULATION

> **NIH NIH R01** · CREIGHTON UNIVERSITY · 1991 · $202,066

## Abstract

This project consists of a longitudinal, prospective study of the
population-at-risk for osteoporosis.  Research subjects are 1914 normal
women who were aged 35-45 at the start of the study in 1967.  Observations
are made once every five years and consist of comprehensive personal,
calcium kinetic, calcium metabolic, hormonal, and physiological
measurements, as well as radiogrammetric and photon-densitometric
measurement of bone mass.  Well over 120 primary and derived variables are
accumulated on each subject.

The purposes of the project are:  1) to obtain comprehensive longitudinal
data on various measures of calcium metabolism, bone metabolism, and
related physiological functions in a group of untreated women from the
perimenopausal period to the median onset time of osteoporotic symptoms; 2)
to provide an exhaustive physiological profile both on women who develop
symptomatic osteoporosis, and on those who do not, thereby allowing
prospective characterization of the differences between them and of the
factor influencing those differences; 3) to permit better identification of
the osteoporosis-prone subset and thereby to provide both a rational basis
for prophylactic treatment and the identification of subjects who should be
its target; 4) to characterize cross-sectional inter-relationships between
major physiological variables during this key era of osteoporosis
development; and finally 5) to provide a comprehensive database for testing
hypotheses about associations among variables developed by us and others
outside the context of this proposal.

The plan is to continue our observations on this cohort until a sufficient
number develop osteoporosis-related fractures.  At the onset of the new
project period the study population will be in the age-range 58-68.
Thirty-three probable fragility-related fractures have occurred in the
cohort to date.  We anticipate seeing substantially more such fractures
developing during this next five-year period.

## Key facts

- **NIH application ID:** 3154669
- **Project number:** 5R01AR007912-26
- **Recipient organization:** CREIGHTON UNIVERSITY
- **SAM.gov UEI:** NH64NT271S93
- **Principal Investigator:** ROBERT P HEANEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $202,066
- **Award type:** 5
- **Project period:** 1979-04-01 → 1994-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154669

## Citation

> US National Institutes of Health, RePORTER application 3154669, LONGITUDINAL STUDY OF A PRE-OSTEOPOROSIS POPULATION (5R01AR007912-26). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3154669. Licensed CC0.

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