# CONNECTIVE TISSUE ACTIVATION IN RHEUMATIC DISEASES

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1987 · $194,966

## Abstract

We propose to isolate selected Connective Tissue Activating Peptides
(CTAPs), and to define their chemical characteristics at a molecular
level.  Immunologic methods will be used to identify, localize and
quantitate relevant human CTAPs in biological samples.  Knowledge of the
mechanisms of action of this class of regulators of connective tissue
metabolism will be extended by identifying factors controlling synthesis
and release of CTAPs, by defining the events occurring at the time of
mediator-cell interaction, and by elucidating early consequences of
activation (altered transport) as well as late events (glycosaminoglycan
and proteoglycan synthesis).  Relevance to rheumatic disease in man will be
defined by studies of distribution and concentration of CTAPs in normal
individuals and rheumatic patients, as well as by testing the therepeutic
potential of selected agonists.  Further, the activated human cell culture
system will continue to be used as a model to test agents with potential
for interdicting the inflammatory process.  Our long-term objective is to
sufficiently understand the mechanisms regulating connective tissue
metabolism in normal man, and in degenerative and inflammatory processes,
so that intelligent definitive intervention may become possible in
rheumatic diseases.

## Key facts

- **NIH application ID:** 3154723
- **Project number:** 5R01AR010728-21
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** C WILLIAM CASTOR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $194,966
- **Award type:** 5
- **Project period:** 1978-02-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154723

## Citation

> US National Institutes of Health, RePORTER application 3154723, CONNECTIVE TISSUE ACTIVATION IN RHEUMATIC DISEASES (5R01AR010728-21). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154723. Licensed CC0.

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