# THE STRUCTURAL BASIS OF CELLULAR FUNCTION

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1989 · $174,394

## Abstract

The objective of this study is the development and testing of a
quantitative optical model of striated muscle for the purpose of
distinguishing between different mechano-chemical transduction
mechanisms.  The birefringence properties of striated muscle will
be determined under a variety of experimental conditions in which
the constituent components of muscle are either organized,
constrained or removed in a well defined manner.  The optical model
will then be used to interpret the birefringence properties of
muscle in terms of parameters which are important for a
quantitative description of the mechano-chemical transduction
process.  The extension of these studies to smooth muscle is also
contemplated.  A full understanding of how chemical energy is
converted into work during muscle contraction is important in many
areas of physiology and medicine.

## Key facts

- **NIH application ID:** 3154763
- **Project number:** 5R01AR012803-30
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** FRANCIS D CARLSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $174,394
- **Award type:** 5
- **Project period:** 1976-12-01 → 1992-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154763

## Citation

> US National Institutes of Health, RePORTER application 3154763, THE STRUCTURAL BASIS OF CELLULAR FUNCTION (5R01AR012803-30). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154763. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*