# STIMULATION OF EXTREMITY GROWTH BY ELECTRICAL FIELDS

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 1988 · $237,200

## Abstract

The object of the proposed reseach is to determine the parameters of a
capacitively coupled electric field required to produce long term growth
stimulation in the lamb proximal radial growth plate as measured
roentgenograhically with the aid of tantalum metaphyseal markers.  A second
objective is to determine the effect of a capacitively coupled electrical
field on intracellular ionized calcium homeostasis, prostaglandin
synthesis, and collagen synthesis and type in bovine growth plate
chondrocytes grown in pellet form and in monolayer, as well as cytoplasmic
components as determined by point-counting analysis of electron micrographs
of rat costochondral junctions grown in organ culture.  The long term
objective is to develop a non-invasive method of stimulating the epiphyseal
growth plate to accelerated growth in those children with limb length
inequality.

## Key facts

- **NIH application ID:** 3154784
- **Project number:** 5R01AR013812-19
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **SAM.gov UEI:** GM1XX56LEP58
- **Principal Investigator:** Carl T. Brighton
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $237,200
- **Award type:** 5
- **Project period:** 1975-11-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154784

## Citation

> US National Institutes of Health, RePORTER application 3154784, STIMULATION OF EXTREMITY GROWTH BY ELECTRICAL FIELDS (5R01AR013812-19). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154784. Licensed CC0.

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