# IMMUNOREACTANTS IN RHEUMATIC DISEASES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1989 · $164,370

## Abstract

Rheumatoid synovial effusions (and other inflammatory joint fluids are
characterized by large numbers of T cells, many of which are activated, and
another ill-defined population lacking cell surface receptors (E negative,
Ig negative, Fc negative).  Little is known about the functional
significance of either population.  There is evidence, however, for natural
killer cell activity mediated by an Fc receptor negative NK cell.  These
characteristics are reminiscent of the results of the in vitro autologous
mixed leukocyte reaction.  We propose to analyze the following hypothesis;
namely, in the rheumatoid joint B lymphocytes, transformed by an undefined
stimulus, generate an autologous MLR.  This leads to activation of T cells
and the elaboration of factors that augment nonspecific cytotoxic
activity.  An additional consequence of this reaction would be the
generation of large amounts of nonspecific T cell-derived helper activity.
This thesis would predict that in the rheumatoid joint one would find
evidence of an increased or secondary type of autologous MLR, an unusual
population of AMLR stimulator cells, the presence of nonspecific cytotoxic
cells lacking Fc receptors, and perhaps specific cytotoxic cells
recognizing lymphocyte membrane defined antigen induced by the B cell
transforming agent.

## Key facts

- **NIH application ID:** 3154823
- **Project number:** 5R01AR014916-19
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** GARY S FIRESTEIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $164,370
- **Award type:** 5
- **Project period:** 1976-05-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154823

## Citation

> US National Institutes of Health, RePORTER application 3154823, IMMUNOREACTANTS IN RHEUMATIC DISEASES (5R01AR014916-19). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3154823. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*