# IMMUNE COMPLEXES IN CHRONIC INFLAMMATION

> **NIH NIH R01** · UNIV OF ARKANSAS FOR MED SCIS · 1993 · $135,104

## Abstract

The overall objective of this proposal is to elucidate the pathogenic
mechanisms of cartilage damage in human arthritis.  It is proposed to
study 1) the interactions of cartilage chondrocytes with anti-collagen
antibodies present in a proportion of synovial fluids of patients with
rheumatoid arthritis, and their effects on chondrocyte function; 2) the
role of oxidative processes mediated by inflammatory cells in synovial
fluids on the generation of noxious lipids peroxides and modified
immunoglobulins, and their effects on chondrocytes, polymorphonuclear
leukocytes and monocytes.  These studies will involve the use of a
variety of biochemical and immunochemical techniques.

## Key facts

- **NIH application ID:** 3154878
- **Project number:** 2R01AR016209-19A1
- **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS
- **SAM.gov UEI:** VDFYLZPJEAV6
- **Principal Investigator:** HUGO E JASIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $135,104
- **Award type:** 2
- **Project period:** 1991-09-30 → 1997-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154878

## Citation

> US National Institutes of Health, RePORTER application 3154878, IMMUNE COMPLEXES IN CHRONIC INFLAMMATION (2R01AR016209-19A1). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3154878. Licensed CC0.

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