# TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT

> **NIH NIH R01** · RUSH UNIVERSITY · 1989 · $166,791

## Abstract

This proposal is concerned with: (1) bone remodeling and associated
structural changes in the proximal femur subsequent to implantation of
porous coated femoral components in cementless total hip arthroplasty (THA)
and (2) revision of failed cemented total hip arthroplasty with porous
coated femoral components.

The premise of bone ingrowth fixation is that the prosthesis will remain
firmly anchored to the host bone indefinitely.  Consequently, complications
due to bone remodeling contitute one of the major long-term concerns.  The
location of the porous coating and the stiffness of the stem are two of the
design parameters likely to influence the mechanical environment and,
hence, remodeling of the proximal femur subsequent to cementless porous
coated THA.  A canine model will be used to provide data on the effect of
these two parameters on bone remodeling and structural changes following
cementless THA.

Radiographic evidence of aseptic loosening has been reported to be as high
as 40% in cemented revision of failed cemented THA.  Cementless porous
coated prosthesis are being used for revision arthroplasty, but it is not
known if bone ingrowth actually occurs in this situation nor are the
long-term effects on bone remodeing known.  A canine revision model and a
canine model of a gap at the interface between the host bone and the porous
coating will be used to provide insight into the process of bone ingrowth,
into the possibility of enhancing this process, and into cortical bone
remodeling following cementless revision THA.

## Key facts

- **NIH application ID:** 3154910
- **Project number:** 5R01AR016485-18
- **Recipient organization:** RUSH UNIVERSITY
- **Principal Investigator:** JORGE O GALANTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $166,791
- **Award type:** 5
- **Project period:** 1979-05-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154910

## Citation

> US National Institutes of Health, RePORTER application 3154910, TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT (5R01AR016485-18). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154910. Licensed CC0.

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