# FACTORS INFLUENCING BONE METABOLISM

> **NIH NIH R01** · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 1989 · $298,644

## Abstract

The regulation of bone resorption and formation by systemic hormones and
local factors will be studied using animal models and organ and cell
cultures.  The effects of local factors including prostaglandins,
macromolecular stimulators and inhibitors of bone resorption will be
examined.  The products of arachidonic acid metabolism in bone will be
characterized and the effects of eiconsanoids on bone formation analyzed.
The relation of local stimulators and inhibitors to osteoclast activating
factor and other stimulators of bone resorption will be examined both
chemically and biologically.  Studies on systemic hormones will include
analysis of the anabolic effect of PTH, the paradoxical osteomalacia
produced by toxic doses of 1,25-(OH)2D and studies on the mechanism of
escape from calcitonin.  Glucocorticoids will be analyzed for their dual
effects and for their relation to changes in endogenous prostaglandin
production.  New models will be developed for the study of hormonal
regulation of mineralization and for the analysis of the role of sex
hormones in bone metabolism.  These studies are intended to increase our
understanding of physiologic and pathologic regulation of bone metabolism
and to provide new insight in the pathogenesis of metabolic bone disease.

## Key facts

- **NIH application ID:** 3154970
- **Project number:** 5R01AR018063-16
- **Recipient organization:** UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- **SAM.gov UEI:** H6D6JMXJXDE6
- **Principal Investigator:** Lawrence Gideon Raisz
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $298,644
- **Award type:** 5
- **Project period:** 1975-03-01 → 1990-09-01

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154970

## Citation

> US National Institutes of Health, RePORTER application 3154970, FACTORS INFLUENCING BONE METABOLISM (5R01AR018063-16). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154970. Licensed CC0.

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