# FACTORS INFLUENCING BONE METABOLISM

> **NIH NIH R01** · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 1992 · $294,140

## Abstract

This project is based on the concept that interactions between local and
systemic factors are important in the regulation of bone metabolism and
that studies of these interactions will provide insight not only into
physiologic regulation of the skeleton, but also into pathologic mechanisms
and therapeutic approaches in metabolic bone disease, particularly
osteoporosis.  The studies proposed will use organ cultures of fetal and
neonatal bone and cell cultures of the osteoblast phenotype, from both
immortalized and transformed cell lines, to examine the complex hormonal
regulation of skeletal tissues.  Our major hypothesis is that endogenous
prostaglandins are central to the ability of the skeleton to respond to
local perturbations and that the role of prostaglandins is continuously
modified by systemic hormones.  The specific avenues to be explored include
studies on the mechanisms of the effects of prostaglandins and related
eicosanoids on bone resorption and formation, analysis of the regulation of
endogenous prostaglandin production in bone, studies on interactions
between prostaglandins, cytokines or growth factors and systemic hormones
such as parathyroid hormone and 1,25 dihydroxyvitamin D.  In addition, we
will attempt to develop a reliable in vitro model to study the mechanism of
the anabolic effect of PTH.  An organ culture model which shows orderly
bone growth with mineralization will be used to determine whether
mineralization is regulated.  We will attempt to find markers for bone
resorption using in vitro models, which can then be used to assess
resorption in vivo.

## Key facts

- **NIH application ID:** 3154971
- **Project number:** 5R01AR018063-18
- **Recipient organization:** UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- **SAM.gov UEI:** H6D6JMXJXDE6
- **Principal Investigator:** Lawrence Gideon Raisz
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $294,140
- **Award type:** 5
- **Project period:** 1975-03-01 → 1995-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3154971

## Citation

> US National Institutes of Health, RePORTER application 3154971, FACTORS INFLUENCING BONE METABOLISM (5R01AR018063-18). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3154971. Licensed CC0.

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