# MECHANICAL CONTROL AND ENERGETICS OF MUSCLE CONTRACTION

> **NIH NIH R01** · OHIO STATE UNIVERSITY · 1988 · $7,150

## Abstract

Work on energetics of muscle has shown that length changes during
contraction modify contractile activity.  The mechanism of this action has
been studied by determining how shortening and lengthening change the
strength and time course of contraction.  Further progress in this work is
expected from the application of these principles to a special type of
muscle fibers, which are known to be very slow, the tonus fibers of frog
muscles.  Preliminary experiments have shown that these fibers can after
brief stimulation stay in a state of contraction for more than an hour at 1
degree, without being active, and continue to give responses to length
changes.  This raises questions of a very basic nature, suggesting that the
contracted state can be maintained without cycling of the crossbridges and
that the strength of contraction can be controlled without the Ca mechanism
initiating contraction.  Work carried out so far indicates that control of
activity follows the same principles in all striated muscles.  It can,
therefore, be expected that the results apply also to the heart.

## Key facts

- **NIH application ID:** 3155099
- **Project number:** 3R01AR020049-11S1
- **Recipient organization:** OHIO STATE UNIVERSITY
- **SAM.gov UEI:** DLWBSLWAJWR1
- **Principal Investigator:** EMIL BOZLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $7,150
- **Award type:** 3
- **Project period:** 1982-09-30 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155099

## Citation

> US National Institutes of Health, RePORTER application 3155099, MECHANICAL CONTROL AND ENERGETICS OF MUSCLE CONTRACTION (3R01AR020049-11S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155099. Licensed CC0.

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