# BIOMECHANICAL STUDY OF TOTAL KNEE REPLACEMENT

> **NIH NIH R01** · RUSH UNIVERSITY · 1989 · $98,823

## Abstract

The continued objective is to provide biomechanical information on the knee
joint that can be used to improve the treatment of arthritis of the knee.
Previous work has indicated that biomechanical function can be influenced
by the design of a total knee replacement.  In addition, recent results
suggest a relationship between dynamic functional loading and clinical
results in patients in patients with high tibial osteotomies.  The goal is
to examine the interrelationships between dynamic functional loading and
clinical results with total knee replacement and high tibial ostetomy.  The
general hypothesis is that dynamic functional loading is related to
post-operative clinical results.

Specific goals relating to this hypothesis are the following:  1) to
identify if time-related functional biomechanical changes can be correlated
with clinical and radiographic changes at five to seven years following
surgery, 2) to identify if correlations exist between pre-operative
functional biomechanics and post-operative functional biomechanics
following total knee replacement, 3) to identify if functional loading
abnormalities can be associated with the use of cementless fixation of
total knee replacement, 4) to validate our initial findings that
pre-operative knee joint loading is strongly predictive of clinical results
in patients with high tibial osteotomies.

Biomechanical functional testing will be conducted for level walking,
stairclimbing and chair rising to determine extrinsic joint movement and
loading patterns.  This information will be analyzed independently as well
as provide input to mathematical and in vitro models to analyze intrinsic
joint loads.  Biomechanical data will be correlated with quantitative
clinical and radiographic evaluations.

Ultimately, this information will be useful in identifying functional
loading characteristics that correlate with clinical results and
radiographic changes.  Adaptive mechanisms will be identified and their
implication to joint alignment, component fixation and clinical outcome
will be evaluted.

## Key facts

- **NIH application ID:** 3155127
- **Project number:** 5R01AR020702-11
- **Recipient organization:** RUSH UNIVERSITY
- **Principal Investigator:** THOMAS P ANDRIACCHI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $98,823
- **Award type:** 5
- **Project period:** 1978-04-01 → 1989-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155127

## Citation

> US National Institutes of Health, RePORTER application 3155127, BIOMECHANICAL STUDY OF TOTAL KNEE REPLACEMENT (5R01AR020702-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155127. Licensed CC0.

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