# NEW LOCAL ANTI-INFLAMMATORY STEROIDS

> **NIH NIH R01** · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · 1987 · $64,848

## Abstract

The esters of steroid acids derived from potent glucocorticoids are being
evaluated as safer anti-inflammatory steroids for local use.  The local
anti-inflammatory activity of these steroid acid esters is equivalent to
their parent compounds, but their systemic activity is weaker and,
furthermore, they are devoid of systemic side effects.  This is in accord
with the concept that steroid acid esters with intact ring structures of
corticoids possess anti-inflammatory activity per se, but upon entry into
the circulatory system from the administration site are hydrolyzed to
steroid acids which are inactive and are readily excreted.  It is proposed
to confirm the findings and validate this concept by pharmacological,
biochemical and metabolic studies.  New steroid acid esters will be
synthesized and comprehensively evaluated as anti-inflammatory agents using
the carrageenan-induced rat paw edema, croton oil-induced ear edema test
and the cotton pellet granuloma bioassay, with respect to various routes of
administration.  To further delineate the mode of action of the steroids,
their effect on pituitary-adrenal function, glycogen deposition,
electrolyte balance, hepatic transaminases, skin collagen synthesis,
interaction with various receptor preparations and leukocyte function
including migration and liberation of prostanoids, elastase and collagenase
will be studied.  The metabolic fate of these steroids in rats will also be
investigated using radiolabeled compounds.

The results of these studies will yield valuable insight into the mode of
action of these new classes of corticosteroids with the promise of
producing a new series of locally acting anti-inflammatory steroids which
are devoid of systemic side effects and thus will be more acceptable for
use in the clinical environment.

## Key facts

- **NIH application ID:** 3155200
- **Project number:** 5R01AR021627-09
- **Recipient organization:** FLORIDA AGRICULTURAL AND MECHANICAL UNIV
- **SAM.gov UEI:** W8LKB16HV1K5
- **Principal Investigator:** HENRY J LEE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $64,848
- **Award type:** 5
- **Project period:** 1979-09-25 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155200

## Citation

> US National Institutes of Health, RePORTER application 3155200, NEW LOCAL ANTI-INFLAMMATORY STEROIDS (5R01AR021627-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155200. Licensed CC0.

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