# BONE AND CARTILAGE ALLOGRAFTS IN BONE TUMOR TREATMENT

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 1989 · $166,367

## Abstract

Our purpose is to continue the study of the use of osteochondral allograft
implantation in the management of patients with skeletal defects as a
result of resection for tumor or disease or traumatic loss.

Experimental studies will include:

1. Continued in depth follow-up of the patients in the clinical series with
special attention to the incidence, cause and nature of complications of
the procedure.

2. Continued assessment of the long term effect of massive allograft
implantation on the host's immune system and the effect of such alterations
on the fate of the graft.

3. Assessment of the state of the graft and causes of failure by study of
the graft material obtained from those patients in whom subsequent removal
of the graft is required because of infection, fracture or tumor recurrence.

4. Determination by prospective and retrospective study of the effect of
adjuvant chemotherapy on the rate of incorporation of the graft and the
rate of the repair process.

5. Introduction of special techniques for evaluating the graft (CT, bone
scanning and NMR) and the patient's performance (gait analysis) in order to
more fully define the patient's status.

6. Continued study of methods to improve banking procedures with special
attention to harvesting, cryopreservation techniques, maintenance of
sterility, computerized record keeping and sizing, and cost containment.

7. Further development of animal models of the osteoarticular allograft
procedure and utilization of these for exploration of the effects of
technical improvements in fixation, cryopreservation, alterations in
histocompatibility and a variety of  immunosuppressive regimens.

8. Continued experimentation on techniques of cryopreservation of cartilage
segments with special attention to cryopreservative agents and conditions
of freezing and thawing.

## Key facts

- **NIH application ID:** 3155216
- **Project number:** 2R01AR021896-11
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **SAM.gov UEI:** FLJ7DQKLL226
- **Principal Investigator:** WILLIAM W TOMFORD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $166,367
- **Award type:** 2
- **Project period:** 1978-12-01 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155216

## Citation

> US National Institutes of Health, RePORTER application 3155216, BONE AND CARTILAGE ALLOGRAFTS IN BONE TUMOR TREATMENT (2R01AR021896-11). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3155216. Licensed CC0.

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