# FACTORS INFLUENCING SURVIVAL OF VASCULARIZED BONE GRAFTS

> **NIH NIH R01** · HOSPITAL FOR SPECIAL SURGERY · 1993 · $149,880

## Abstract

The specific aims of this application are to continue the investigation
of factors influencing the principles of vascularized bone grafts.
Currently available vascularized bone grafts used to reconstruct massive
segmental bone loss in compromised beds following wide resections of
malignant bone tumors, traumatic bony defects, and infected non-unions
have significant limitations resulting from structural confirmation of
the graft, and donor site morbidity.  The central goal of this proposal
is to utilize biosynthetic components (hydroxyapatite ceramic mold),
osteoinductive principles and osteoprogenitor cells coupled with a
vascularized pedicle to produce "a molded vascularized osteogenesis".

The second goal of this proposal is to isolate bone marrow stromal
osteoprogenitor cells, determine the appropriate degree of
differentiation that maximizes osteogenesis in vivo and expand this to
defined populations ex vivo prior to utilization in molded osteogenesis.
Studies have been designed to isolate the characterize osteoprogenitor
cells from rabbit marrow in vitro and utilize diffusion chambers to
determine the appropriate level of contact with matrix host cells and to
determine the effects of demineralized bone matrix and of growth factors
on heterotopic bone regeneration.  This vascularized molded bone graft
will be used as an island graft or a free transfer and the healing and
material properties of these grafts will be examined and compared to
conventional bone grafts.

## Key facts

- **NIH application ID:** 3155352
- **Project number:** 2R01AR025791-12A2
- **Recipient organization:** HOSPITAL FOR SPECIAL SURGERY
- **Principal Investigator:** Joseph Michael Lane
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $149,880
- **Award type:** 2
- **Project period:** 1979-07-01 → 1993-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155352

## Citation

> US National Institutes of Health, RePORTER application 3155352, FACTORS INFLUENCING SURVIVAL OF VASCULARIZED BONE GRAFTS (2R01AR025791-12A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155352. Licensed CC0.

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