# ORTHOPEDIC SEPSIS:  PATHOGENESIS, DIAGNOSIS, & TREATMENT

> **NIH NIH R01** · MAYO CLINIC ROCHESTER · 1987 · $99,869

## Abstract

This project is designed to provide some insight into the pathophysiology,
diagnosis, and treatment of acute osteomyelitis; the treatment of chronic
osteomyelitis; and the treatment of the infected total hip arthroplasty.

The initial phase of this project will address the treatment of chronic
osteomyelitis with a local muscle flap.  The goal of this phase is
two-fold:  1) to document the usefulness of non-invasive examinations with
dynamic 99m technetium scintigraphy and magnetic resonance imaging in the
diagnosis and monitoring of therapy; and 2) to determine if parenteral
antibiotic therapy can be reduced from four to two weeks with the use of a
muscle flap.

The second phase of this project will delve into the pathophysiology,
diagnosis, and treatment of acute osteomyelitis in immature osseous
tissue.  Three non-invasive techniques - dynamic 99m technetium
scintigraphy, magnetic resonance imaging, and 111 indium leukocyte imaging
- will be compared in the diagnosis of acute osteomyelitis.  Histological
evaluation of the phagocytic capabilities of tissue based macrophages in
the ascending and descending capillary loops of the growth plate will be
analyzed with gram-stains of tissue, immunofluorescence, and electron
microscopy of the tissue.  The timing and duration of antibiotic therapy
will be studied.

The final phase of this project will compare "one-stage" exchange
arthroplasty utilizing gentamicin impregnated acrylic cement with delayed
reconstruction utilizing an ingrowth implant.

## Key facts

- **NIH application ID:** 3155471
- **Project number:** 5R01AR026928-07
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **SAM.gov UEI:** Y2K4F9RPRRG7
- **Principal Investigator:** ROBERT H FITZGERALD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $99,869
- **Award type:** 5
- **Project period:** 1980-04-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155471

## Citation

> US National Institutes of Health, RePORTER application 3155471, ORTHOPEDIC SEPSIS:  PATHOGENESIS, DIAGNOSIS, & TREATMENT (5R01AR026928-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155471. Licensed CC0.

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