# AN INVESTIGATION OF JOINT DEGENERATION

> **NIH NIH R01** · WEST VIRGINIA UNIVERSITY · 1988 · $231,752

## Abstract

We plan to study the factors promoting progressive cartilage
destruction in animal models of osteoarthrosis (Degenerative Joint
Disease) to understand its pathophysiology in order to work toward
its prevention.  Since the pathology of osteoarthrosis involves
destruction of the articular cartilage and the remodeling of the
bone adjacent to the joints, we must use in vivo preparations.
Because osteoarthrosis mainly affects older individuals and its
development involves an interrelationship between a variety of
tissues, organ cultures utilizing fetal materials are
inappropriate.   The effectiveness and reliance of our animal
models has been established.  The joint tissues are studied
biochemically, metabolically and biomechanically.  Having
identified the initial tissue changes in osteoarthrosis we are now
completing our study of the inter-relationships of the changes in
bone, cartilage, and synovium to determine what makes joint
deterioration progressive.  We wish to continue our experiments
designed to prevent mechanically induced joint deterioration from
becoming progressive.  We will use inter-related computer models
and experimental models.  In the process we are working to identify
the threshold insults that provoke osteoarthrosis.  Experimentally
we will use both mechanical and antimetabolic means to prevent and
suppress the critical steps in the development of osteoarthrosis
from occurring.

## Key facts

- **NIH application ID:** 3155512
- **Project number:** 2R01AR027127-08
- **Recipient organization:** WEST VIRGINIA UNIVERSITY
- **SAM.gov UEI:** M7PNRH24BBM8
- **Principal Investigator:** ERIC L RADIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $231,752
- **Award type:** 2
- **Project period:** 1979-09-30 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155512

## Citation

> US National Institutes of Health, RePORTER application 3155512, AN INVESTIGATION OF JOINT DEGENERATION (2R01AR027127-08). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3155512. Licensed CC0.

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