# PLATELETS IN RHEUMATIC DISEASE

> **NIH NIH R01** · SCRIPPS RESEARCH INSTITUTE, THE · 1990 · $165,688

## Abstract

The experiments described in this proposal are designed to clarify the mechnisms
of platelet participation in inflammation.  To do this, three areas will be
studied:  1)  The mechanisms of platelet stimulation by inflammatory stimuli;
monosodium urate crystals are potent phlogistic agents in man and occur
pathologically in human gout.  These crystals stimulate platelets in vitro.  To
elucidate the mechanism(s) whereby these agents stimulate platelets, platelet
surface proteins which interact with urate crystals will be characterized.  In
addition, the roles of C1 and fibronectin, which have been proposed to be
platelet surface receptors, in platelet stmulation by urate crystals will be
evaluated.  2)  The mechanism of secretion of platelet "alpha granule
constituents: Platelet alpha granules contain a variety of proteins which may be
involved in the production of or response to tissue injury.  We will elucidate
the mechanism whereby the contents of these granules are released from
stimulated platelets.  3)  Detection of platelet activation and localization in
vivo in experimentally induced inflammation.

## Key facts

- **NIH application ID:** 3155534
- **Project number:** 5R01AR027214-10
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **SAM.gov UEI:** PHZJFZ32NKH4
- **Principal Investigator:** Mark HOWARD Ginsberg
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $165,688
- **Award type:** 5
- **Project period:** 1980-08-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155534

## Citation

> US National Institutes of Health, RePORTER application 3155534, PLATELETS IN RHEUMATIC DISEASE (5R01AR027214-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155534. Licensed CC0.

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