# PATHOGENESIS OF RETROVIRUS INDUCED ARTHRITIS

> **NIH NIH R01** · WASHINGTON STATE UNIVERSITY · 1991 · $167,297

## Abstract

Caprine arthritis-encephalitis virus (CAEV) is a lentivirus related
to the ovine maedi/visna and equine infectious anemia viruses and
to the human lentivirus implicated in acquired immune deficiency
syndrome.  CAEV causes a complex inflammatory disease syndrome in
domestic goats characterized principally by progressive arthritis
in adults.  The insidious course of CAE arthritis and the resultant
pathology are markedly similar to the chronic human arthritides,
particularly rheumatoid arthritis.  CAE arthritis is caused by
immunopathologic processes initiated by immune responses to the
viral gp135 envelope glycoprotein.  The progressive course of
disease is maintained by persistent viral antigen expression in
the presence of anti-viral immune responses.  The objective of
studies in this laboratory is to define the immunologic and
virologic mechanisms involved in disease pathogenesis.  This
proposal will evaluate mechanisms that may contribute to persistent
virus replication and disease, including (1) establishment of
latently-infected cells in which viral gene expression is
restricted and (2) emergence and selection of virus expressing
antigenic variation of gp135.  These studies may also be relevant
to the development of protective immunization strategies for
persistent lentiviral disease.

## Key facts

- **NIH application ID:** 3155561
- **Project number:** 5R01AR027680-11
- **Recipient organization:** WASHINGTON STATE UNIVERSITY
- **SAM.gov UEI:** XRJSGX384TD6
- **Principal Investigator:** WILLIAM P CHEEVERS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $167,297
- **Award type:** 5
- **Project period:** 1981-02-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155561

## Citation

> US National Institutes of Health, RePORTER application 3155561, PATHOGENESIS OF RETROVIRUS INDUCED ARTHRITIS (5R01AR027680-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155561. Licensed CC0.

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