# TRANSPORT AND QUANTITATION OF VITAMIN D STEROLS

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 1987 · $163,331

## Abstract

A research program is proposed which examines several aspects of the transport,
distribution and metabolism of vitamin D and its metabolities.  This proposal
seeks to acquire specific and detailed information about the delivery and
metabolism of antiricket sterols, and to apply these findings, where possible,
to the study of human physiology and disease.  Two major areas of research are
proposed.  Project one aims to examine, by means of new or existing specific
assays for vitamin D metabolites, the physiologic and pathologic influences
which control vitamin D metabolism in man.  Serial examination of vitamin D
metabolite concentrations in human serum is designed to further our diagnostic
and therapeutic capabilities in clinical disorders of mineral homeostasis.
Project two deals with the serum and tissue binding proteins for antiricketic
sterols, and aims to examine the specific nature of sterol transfer into
tissues.  Studies are designed to isolate binding proteins, examine the
regulation of their synthesis, explore the possibility of specific interactions
between serum binding proteins and cell surface and intracellular proteins, and
examine the interaction of sterol-binding complexes with intra-cellular
organelles.

## Key facts

- **NIH application ID:** 3155622
- **Project number:** 5R01AR028292-07
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **SAM.gov UEI:** GM1XX56LEP58
- **Principal Investigator:** PETER J. SNYDER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $163,331
- **Award type:** 5
- **Project period:** 1980-08-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155622

## Citation

> US National Institutes of Health, RePORTER application 3155622, TRANSPORT AND QUANTITATION OF VITAMIN D STEROLS (5R01AR028292-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155622. Licensed CC0.

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