# COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS

> **NIH NIH R01** · DUKE UNIVERSITY · 1987 · $145,518

## Abstract

Collagen is the major structural protein of the body and recent studies
have emphasized its role in other biological processes including
differentiation and cell adhesion.  Connective tissue abnormalities which
may be related to biological properties of collagen occur throughout
medicine.  These include fibrotic conditions, osteoporosis, wound healing,
developmental defects, and aging.  Human skin fibroblasts in culture devote
a considerable portion of their biosynthetic capacities to collagen
production and provide a convenient means for studying the regulation of
its synthesis.  Collagen synthesis including type-specific synthesis and
levels of modifying enzymes (lysyl hydroxylase and prolyl hydroxylase) will
be studied.  An attempt will be made to understand the role and level of
regulatory influences including hormonal and nutritional on collagen
production in these cells.

## Key facts

- **NIH application ID:** 3155632
- **Project number:** 5R01AR028304-06
- **Recipient organization:** DUKE UNIVERSITY
- **SAM.gov UEI:** TP7EK8DZV6N5
- **Principal Investigator:** SHELDON R PINNELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $145,518
- **Award type:** 5
- **Project period:** 1981-04-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155632

## Citation

> US National Institutes of Health, RePORTER application 3155632, COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS (5R01AR028304-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155632. Licensed CC0.

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