# COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS

> **NIH NIH R01** · DUKE UNIVERSITY · 1992 · $137,960

## Abstract

Collagen is the major structural protein in the body and one that plays an
important role in such diverse biological functions as differentiation,
remodeling, wound repair, and aging.  Human skin fibroblasts in culture
devote a large portion of their protein synthetic capacity to collagen,
thus providing a convenient system for studying regulation of collagen
synthesis.  Our ongoing studies are concerned with regulation of the
expression of collagen genes as well as the collagen-specific enzymes
prolyl hydroxylase and lysyl hydroxylase, especially with respect to
ascorbic acid, an inducer of collagen synthesis, and minoxidil, a drug that
we have recently found to specifically inhibit the synthesis of lysyl
hydroxylase.  We propose studies designed to understand the mechanism of
these effects at the molecular level.

## Key facts

- **NIH application ID:** 3155635
- **Project number:** 5R01AR028304-10
- **Recipient organization:** DUKE UNIVERSITY
- **SAM.gov UEI:** TP7EK8DZV6N5
- **Principal Investigator:** SHELDON R PINNELL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $137,960
- **Award type:** 5
- **Project period:** 1981-04-01 → 1993-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155635

## Citation

> US National Institutes of Health, RePORTER application 3155635, COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS (5R01AR028304-10). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3155635. Licensed CC0.

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