# EVALUATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1991 · $175,468

## Abstract

The long term failure rate of total joint replacement makes it an
unsuitable selection for the treatment of arthritis in the young and middle
aged patient.  A more appropriate treatment for these patients is a
procedure that restores the joint surfaces back to their normal state with
biologically competent tissues.  It has been demonstrated that rib
perichondrium transplanted into a joint will proliferate to form a hyaline
cartilage, and that this neocartilage continues to mature until it is
almost identical to the tissue it is replacing.

The objectives of this proposal are to further develop a technique for
grafting a large full-thickness cartilage defect in the rabbit knee femoral
condyle.  A systematic evaluation of different combinations of carrier and
cellular source will be performed, with emphasis on allogenic demineralized
bone vs porous polylactic acid as the carrier material, and perichondrial
tissue vs cells derived from perichondrium in cell cultures as the cell
source.  Additionally, growth factors known to affect cartilage cell
replication and matrix production will be tested in an in vivo model.
Results of these studies will be done by using morphological, histological,
biochemical and biomechanical methodologies.  By following the principles
of placement of an appropriate stem cell into a cartilage defect by
attachment to a carrier that can be entrapped in the bone underlying the
defect, we expect to develop a technique for reliable repair of human
cartilage defects.

## Key facts

- **NIH application ID:** 3155668
- **Project number:** 2R01AR028467-10
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** RICHARD D COUTTS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $175,468
- **Award type:** 2
- **Project period:** 1981-04-01 → 1995-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155668

## Citation

> US National Institutes of Health, RePORTER application 3155668, EVALUATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM (2R01AR028467-10). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3155668. Licensed CC0.

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