# EVALUATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1990 · $180,318

## Abstract

The long term failure rate of total joint replacement makes it an
unsuitable selection for the treatment of arthritis in the young
and middle aged patient.  A more appropriate treatment for these
patients is a procedure that restores the joint surfaces back to
their normal state with biologically competent tissues.  It has
been demonstrated that rib perichondrium transplanted into a joint
will proliferate to form a hyaline cartilage, and that this
neocartilage continues to mature until it is almost identical to
the tissue it is replacing.

The objectives of this proposal are to develop and test a system
of graft fixation wherein the perichondrium is secured to a bone
plug utilizing a dacron mesh laid over the perichondrium.  The
composite dacron perichondrium/bone plug will be placed into the
medial femoral condyle of the rabbit.  The knee will be treated for
2 wks. with intermittent continuous passive motion.  The
regenerated neocartilage will be studied both short term (6-12
wks.) and long term (26, 52, 78 and 104 wks.) and will be evaluated
using morphological, biochemical and biomechanical techniques.
Normal articular cartilage will serve as a control.  The goal is
to achieve a clinical biologically acceptable result from
perichondrial transplantation.

## Key facts

- **NIH application ID:** 3155671
- **Project number:** 5R01AR028467-09
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** RICHARD D COUTTS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $180,318
- **Award type:** 5
- **Project period:** 1981-04-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155671

## Citation

> US National Institutes of Health, RePORTER application 3155671, EVALUATION OF CARTILAGE GROWN FROM RIB PERICHONDRIUM (5R01AR028467-09). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3155671. Licensed CC0.

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