# MALIGNANCY-ASSOCIATED HYPERCALCEMIA

> **NIH NIH R01** · YALE UNIVERSITY · 1991 · $313,864

## Abstract

Humoral hypercalcemia of malignancy is a common
paraneoplastic syndrome.  The peptide factor or factors mediating
this syndrome has not been previously identified.  The two most
active hypotheses at present are that the factor in question is a
parathyroid hormone-like peptide or a growth factor-peptide.

In ongoing studies, we have 1) fully characterized a number of
animal models of the humoral syndrome and have identified a
similar factor as a secretary product of normal keratinocytes, 2)
purified and sequenced peptides from a human and a rat tumor,
with the human tumor peptide revealing an aminoterminal region
of striking homology to human parathyroid hormone, 3)
constructed a cDNA library from a renal human carcinoma
mRNA, and 4) begun to study the actions of the tumor-derived
peptide at the level of its two key target tissues, bone and kidney.

The principle goals of the present proposal include:  1) to continue
our purification and sequencing efforts using tumors from humans
and several other species, 2) to develop polyclonal and monoclonal
antibodies to the human and rat peptides, 3) to identify and
sequence a fulllength cDNA and initiate a broad range of
molecular projects, and 4) to expand and refine out studies of the
factor's actions on bone and renal cells.

## Key facts

- **NIH application ID:** 3155747
- **Project number:** 5R01AR030102-11
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** Arthur Eastwood Broadus
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $313,864
- **Award type:** 5
- **Project period:** 1981-07-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155747

## Citation

> US National Institutes of Health, RePORTER application 3155747, MALIGNANCY-ASSOCIATED HYPERCALCEMIA (5R01AR030102-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155747. Licensed CC0.

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