# PATHOGNESIS AND THERAPY OF EXPERIMENTAL OSTEOARTHRITIS

> **NIH NIH R01** · CASE WESTERN RESERVE UNIVERSITY · 1991 · $175,074

## Abstract

Osteoarthritis (OA, degenerative joint disease) is the most
common form of arthritis.  It occurs almost universally in the
aged, and results in significant disability in over 20% of patients.
Although the etiology of OA is unknown, studies suggest etiologic
roles for biochemical, chemical, inflammatory and immunologic
factors.  It has become increasingly evident that interplays of
synovium, cartilage and bone contribute in significant fashion to
primary and augmenting pathophysiologic processes.  This
proposal is designed to 1)  use monoclonal antibodies to separately
identify serum antigen or antibody markers which reflect
cartilage (proteoglycans, glycosaminoglycans, type II collagen), or
bone (type I collagen; bone derived CSA, cartilage-stimulating
activity factor) so as to noninvasively study cartilage/bone
changes in osteoarthritic, normal and aging joints in experimental
models and in humans; 2) investigate sequential tissue changes in
cartilage lesions in experimental OA using monoclonal antibodies
which recognize specific epitopes on rabbit cartilage
proteoglycans; and 3) determine the role of immune factors in
augmentation of degradative and (secondary) inflammatory
changes observed in experimental OA.  The relationship of
immunoglobulin deposition to evolving pathologic changes will be
studied, and reactive antigenic determinants defined.
Immunochemical responses of cartilage components to
biomechanical, hormonal and biochemical manipulations will be
investigated.  Studies will provide insights in osteoarthritis
pathophysiology and allow for advances in disease definition and
diagnosis.

## Key facts

- **NIH application ID:** 3155759
- **Project number:** 5R01AR030134-13
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **SAM.gov UEI:** HJMKEF7EJW69
- **Principal Investigator:** ROLAND W MOSKOWITZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $175,074
- **Award type:** 5
- **Project period:** 1981-12-01 → 1991-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155759

## Citation

> US National Institutes of Health, RePORTER application 3155759, PATHOGNESIS AND THERAPY OF EXPERIMENTAL OSTEOARTHRITIS (5R01AR030134-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155759. Licensed CC0.

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