# ROLE OF PEPTIDE GROWTH FACTORS IN SKELETAL DEVELOPMENT

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 1990 · $170,677

## Abstract

The purpose of the proposed studies is to examine the role of
somatomedin in certain aspects of skeletal development and
pathology.

One specific aim of these studies is to test the controversial
hypothesis that the action of growth hormone (GH) on skeletal
growth is mediated by somatomedin-C/Insulin-Like Growth Factor I
(Sm-C/IGF-I).  The cells responsible for skeletal growth are the
chondrocytes of the epiphyseal growth plate.  Newly developed
molecular biological techniques coupled with culture, RIA,
immunoinhibition, and histological techniques will be used to
investigate the relationships between GH and somatomedin on growth
plate chondrocytes in vitro and in vivo.

A further aim is to examine the role of somatomedin in growth plate
development.  The growth plate is a developmental unit containing
cells at various stages of maturation.  The relationship between
somatomedin and cellular development in the growth plate will be
examined using molecular biological, immunocytochemical and culture
techniques.

Expanding upon these studies, an additional objective of this
proposal is to explore the possibility that Sm-C/IGF-I and
fibroblast growth factor play a combine role in regulating growth.
This work will employ radioligand binding and cell culture
techniques to investigate Sm-C/IGF-I and FGF interactions with
growth plate chondrocytes in vitro.

The long term objective of these studies is to help achieve a basic
understanding of the mechanisms of skeletal growth and development.
Only with such understanding can needed improvements in existing
therapy eventually be achieved.

## Key facts

- **NIH application ID:** 3155969
- **Project number:** 5R01AR031068-08
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **SAM.gov UEI:** FLJ7DQKLL226
- **Principal Investigator:** STEPHEN B. TRIPPEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $170,677
- **Award type:** 5
- **Project period:** 1981-09-01 → 1993-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3155969

## Citation

> US National Institutes of Health, RePORTER application 3155969, ROLE OF PEPTIDE GROWTH FACTORS IN SKELETAL DEVELOPMENT (5R01AR031068-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3155969. Licensed CC0.

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