# AN EXPERIMENTAL MODEL FOR SCLERODERMA

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 1988 · $110,252

## Abstract

This project will explore an experimental model of scleroderma in the
mouse.  The model is based on (a) the probable involvement of autoimmune
immunopathologic processes in idiopathic scleroderma, and (b) the
production of a scleroderma-like illness in human graft-versus-host disease
(GVHD), as well as in chronic GVHD in rodents.  We plan to define the
requirements for establishing and boosting a chronic GVHD in mice across
various histocompatibility barriers.  We will follow skin histopathology
and autoimmune antibodies, and will study the role of the thymus and of
cyclophosphamide on GVHD.  The modulation of skin changes, including
fibronectin deposition, and the effects of bleomycin will be measured.
These studies should provide insight into the nature of the changes found
in idiopathic scleroderma (progressive systemic sclerosis) and on the
tissue injury seen in chronic GVHD.

## Key facts

- **NIH application ID:** 3156002
- **Project number:** 5R01AR031220-06
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **SAM.gov UEI:** MW8JHK6ZYEX8
- **Principal Investigator:** HENRY N CLAMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $110,252
- **Award type:** 5
- **Project period:** 1982-07-01 → 1989-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156002

## Citation

> US National Institutes of Health, RePORTER application 3156002, AN EXPERIMENTAL MODEL FOR SCLERODERMA (5R01AR031220-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156002. Licensed CC0.

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