# EPIDEMIOLOGY OF RAYNAUD PHENOMENON

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 1987 · $75,019

## Abstract

The overall goal of this proposal is to obtain prevalence figures of
Raynaud phenomenon (RP) in the general population based on objective
criteria, to define the risk factors associated with a serious outcome of
RP, and to study the evolution of RP and associated findings during a
follow-up period.  The project will consist of 5 interrelated studies:  1)
questionnaire data on cold sensitivity from population survey, 2) field
examinations to objectively determine the presence of RP, 3) clinical
evaluation and experimental studies of the survey subjects suffering from
RP and their controls at the Arthritis Center in Charleston, SC, 40
case-control study of survey subjects compared to clinic patients belonging
to the same spectrum of RP - connective tissue disease (CTD) continuum and
5) prospective cohort study of a subgroup of survey with RP and suspected
early CTD and their matched idiopathic RP (IRP) controls.  The following
experimental variables will be studied:  digital blood flow, digital blood
pressure, capillary morphology, capillary blood flow, capillary blood
pressure, rheological factors, such as platelet aggregation and
Beta-thromboglobulin levels, and antinuclear antibodies.  The capillary
abnormalities of scleroderma (SD)-type will also be used as predictors in
the prospective study.  The results of this study will provide a basis that
we present lack for estimating the risk of CTD in patients presenting with
RP as well as the probability that they may have a benign IRP.  In
addition, we hope to determine the relative proportions of patients with a
mild, slowly progressing form of SD and those with classical SD by
comparing our survey figures of suspected early SD with previously reported
prevalence rates of classical SD.  Moreover, such early detection of CTD
will improve our understanding of early preclinical pathogenetic mechanisms
in these disorders.

## Key facts

- **NIH application ID:** 3156023
- **Project number:** 3R01AR031283-05S1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **SAM.gov UEI:** NHV3GTWSALA7
- **Principal Investigator:** HILDEGARD R MARICQ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $75,019
- **Award type:** 3
- **Project period:** 1982-08-01 → 1987-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156023

## Citation

> US National Institutes of Health, RePORTER application 3156023, EPIDEMIOLOGY OF RAYNAUD PHENOMENON (3R01AR031283-05S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156023. Licensed CC0.

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