# TRABECULAR BONE REMODELING--RESPONSE TO APPLIED STRESS

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1988 · $200,924

## Abstract

This project is designed to investigate the functional relationship between
the loading characteristics of total joint components and remodeling of the
supporting trabecular bone.  The specific objective is to identify the
optimum stress parameters which promote positive trabecular bone remodeling.

Utilizing implantable load transmitting devices, the dynamic response of
canine metaphyseal trabecular bone to controlled loading, stimuli will be
measured.  The phases of the study will include:

1. Fabrication and calibration of the implanted load delivery system;

2. Assessment and documentation of all control variables and measurements;

3. Measurement and analysis of trabecular bone remodeling responses to
experimentally controlled stress fields.

The experimental variables will be measured using the following
techniques:  computed axial tomography, histologic section and
fluorescence, mechanical materials testing, ash weight determination, and
three dimensional micro computed tomography.

## Key facts

- **NIH application ID:** 3156094
- **Project number:** 5R01AR031793-05
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** Steven A Goldstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $200,924
- **Award type:** 5
- **Project period:** 1983-12-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156094

## Citation

> US National Institutes of Health, RePORTER application 3156094, TRABECULAR BONE REMODELING--RESPONSE TO APPLIED STRESS (5R01AR031793-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156094. Licensed CC0.

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