# TRABECULAR BONE REMODELING--RESPONSE TO APPLIED STRESS

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1992 · $240,680

## Abstract

This research program is designed to investigate the functional
relationship between the loading characteristics of total joint
components and remodeling of the supporting trabecular bone.  In order to
investigate these relationships, a hydraulically activated implant has
been developed which when interfaced with a plane of trabecular bone in
the distal femoral metaphysis of large dogs enables experimental control
of the loading magnitude, frequency, number of cycles, and loading rate.
This implant has already been demonstrated to elicit significant
trabecular bone remodeling at the loading platen bone interface.  These
remodeling responses are characterized utilizing three-dimensional
microcomputed tomography, histologic analysis, and mechanical testing.
          The specific objective of this proposal is to evaluate the
relationship between implant design characteristics and trabecular bone
ingrowth and remodeling.  The quality of bone ingrowth as well as the
morphology and architecture of the adjacent bone will be documented as a
function of controlled implant mediated load.

## Key facts

- **NIH application ID:** 3156095
- **Project number:** 5R01AR031793-07
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** Steven A Goldstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $240,680
- **Award type:** 5
- **Project period:** 1983-12-01 → 1994-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156095

## Citation

> US National Institutes of Health, RePORTER application 3156095, TRABECULAR BONE REMODELING--RESPONSE TO APPLIED STRESS (5R01AR031793-07). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3156095. Licensed CC0.

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