# ANGIOTENSINS IN CUTANEOUS INFLAMMATION & DISEASE

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1987 · $222,796

## Abstract

This proposal is divided into (1) study of the contribution of mast cell and
eosinophil-dependent pathways to the pathogenesis of the human cutaneous
blistering disorder bullous pemphigoid, and (2) isolation, characterization, and
development of specific assays for components of the human neutrophil neutral
peptide generating pathway, so as to permit study of this pathway in appropriate
human cutaneous disorders.  Neutrophil, eosinophil and lymphocyte chemotactic
factors from bullous pemphigoid blister fluid will be purified and characterized
so that their targets in human skin and their cell of origin may be determined.
The cellular and humoral contribution to the regulation of histamine in bullous
pemphigoid blister fluid will be studied.  The chemical data will be correlated
with the order of pathologic alterations as determined by electron microscopic
and histopathologic study of developing skin lesions.
Components of the neutrophil pathway for the generation of a neutral peptide
mediator and the degradation of fibrinogen and fibrin will be fully
characterized.  The neutral peptide product will be purified, characterized,
structurally defined and synthesized in vitro.  The biology of components of
this pathway will be studied and specific immunoassays will be developed for
quantitation of each component in complex biologic fluids and detection in
tissue.

## Key facts

- **NIH application ID:** 3156144
- **Project number:** 5R01AR031901-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** BRUCE U WINTROUB
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $222,796
- **Award type:** 5
- **Project period:** 1982-07-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156144

## Citation

> US National Institutes of Health, RePORTER application 3156144, ANGIOTENSINS IN CUTANEOUS INFLAMMATION & DISEASE (5R01AR031901-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156144. Licensed CC0.

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