# AUTOIMMUNE ARTHRITIS: DISEASE/PROTECTION BY T CELL CLONE

> **NIH NIH R01** · WEIZMANN INSTITUTE OF SCIENCE · 1987 · $63,328

## Abstract

The present proposal is a continuation of our research into the
pathogenesis and manipulation of adjuvant arthritis in Lewis rats using
long-term lines and clones of T lymphocytes.  One clone, A2b, could induce
arthritis but not vaccinate against it.  A second clone, A2c, in contrast,
was not arthritogenic, but was only capable of inducing resistance to
arthritis after a single intravenous inoculation of A2c.  A2c could induce
rapid and long-lasting remission in rats suffering from ongoing adjuvant
arthritis.  Thus, clone A2b served as a vehicle for investigating
pathogenesis of arthritis and clone A2c served as an agent for studying
manipulation of disease.  A2b was found to respond to cartilage
proteoglycan in addition to MT, indicating that adjuvant arthritis may
arise through cross-reactivity between a bacterial epitope and a component
of joint cartilage.  We have also identified several monoclonal
anti-mycobacterial antibodies that recognize cartilage proteoglycan.  The
specific aims of the present proposal are to use arthritogenic clones and
the monoclonal antibodies to define the antigenic relationship between MT
and cartilage responsible for arthritis, and to use protective clones to
elucidate the mechanism of induced resistance to arthritis as follows:

a. Characterization of antigens of cartilage proteoglycans and mycobacteria
recognized by arthritogenic or protective T lymphocyte clones and by
cross-reactive monoclonal antibodies.

b. Investigation of vaccination and therapy mediated by T lymphocyte
clones:  optimization of induction and analysis of mechanism.

c. Development of clonotypic antibodies defining idiotypes of arthritogenic
and protective clones.  Use of anti-idiotypic antibodies to study and
manipulate adjuvant arthritis.

## Key facts

- **NIH application ID:** 3156215
- **Project number:** 5R01AR032192-05
- **Recipient organization:** WEIZMANN INSTITUTE OF SCIENCE
- **SAM.gov UEI:** NPJ8YBLFTKX6
- **Principal Investigator:** IRUN R COHEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $63,328
- **Award type:** 5
- **Project period:** 1983-04-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156215

## Citation

> US National Institutes of Health, RePORTER application 3156215, AUTOIMMUNE ARTHRITIS: DISEASE/PROTECTION BY T CELL CLONE (5R01AR032192-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156215. Licensed CC0.

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