# ANTI-DNA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

> **NIH NIH R01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 1988 · $258,895

## Abstract

Through the analysis of selected idiotypes, we hope to continue our
characterization of anti-DNA antibodies in the human disease, systemic
lupus erythematosus, and in two murine models.  New anti-idiotypes will be
generated to identify the structural basis for DNA binding and to
characterize subsets of anti-DNA antibodies that differ in pathogenicity.
We will generate idiotype positive anti-DNA antibody producing cell lines
from SLE patients and from autoimmune mice.  Using these lines, we will
determine whether there are germ line immunoglobulin variable region genes
that encode anti-DNA antibodies or whether anti-DNA antibodies are the
consequence of somatic mutation in germ line immunoglobulin genes.

## Key facts

- **NIH application ID:** 3156268
- **Project number:** 5R01AR032371-06
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Betty Diamond
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $258,895
- **Award type:** 5
- **Project period:** 1983-04-01 → 1991-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156268

## Citation

> US National Institutes of Health, RePORTER application 3156268, ANTI-DNA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS (5R01AR032371-06). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3156268. Licensed CC0.

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