# ANTI-DNA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

> **NIH NIH R01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 1992 · $294,541

## Abstract

We have identified three cross reactive idiotypes on anti-double stranded
DNA antibodies in systemic lupus erythematosus in man.  The 3I kappa light
chain idiotype is encoded by the Vk1 gene family; the F4 heavy chain
idiotype by the VH3 or VH4 gene family and the 8.12 lambda light chain
idiotype by the V2 gene family.  Having identified the V gene families
associated with the cross reactive idiotypes, we now propose to determine
if particular members of these V region families encode anti-DNA antibodies
and if there are polymorphisms of these V region genes that predispose to
SLE.  We will study multiple antibodies produced by clonally related B cell
lines, B cell genealogies, to identify structural determinants of DNA
binding and assess the role of antigen, and DNA in particular in the anti-
DNA response.  We will determine the relationship of idiotypic anti-DNA
antibodies to anti-pneumococcal polysaccharide antibodies bearing the 3I or
8.12 cross-reactive idiotype.  Finally, we will initiate studies aimed at
defining the structural correlates of pathogenicity of anti-DNA antibodies
and at identifying the T cells that participate in the anti-DNA response in
SLE.

## Key facts

- **NIH application ID:** 3156271
- **Project number:** 5R01AR032371-10
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Betty Diamond
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $294,541
- **Award type:** 5
- **Project period:** 1983-04-01 → 1996-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156271

## Citation

> US National Institutes of Health, RePORTER application 3156271, ANTI-DNA ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS (5R01AR032371-10). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3156271. Licensed CC0.

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