# STRUCTURAL AND CHEMICAL DYNAMICS OF CELL MOVEMENT

> **NIH NIH R01** · CARNEGIE-MELLON UNIVERSITY · 1990 · $190,926

## Abstract

The proposed research is aimed at bridging the gap of knowledge between the
biochemistry, ultrastructure and cell physiology of cytoplasmic structure
and contractility in non-muscle cells.  The experiments take advantage of
the developments from the last grant period in identifying actin-binding
proteins, in developing quantitative fluoresence micropscopic assays, in
proposing a working hypothesis on the relationship between cytoplasmic
structure and contraction, and in implementing quantitative imaging
techniques for basic questions in cell biology.  The proposed experiment
will continue the plan of integrating information obtained from motile cell
extracts, reconstituted cell models, and from living cells.  Changes in
free [Ca++], pH, solation of the actin-based cytoskeleton, and contraction
will be measured in in vitro models and in living cells.  In addition, a
critical test of the solation-contraction coupling hypothesis is proposed.

## Key facts

- **NIH application ID:** 3156307
- **Project number:** 5R01AR032461-09
- **Recipient organization:** CARNEGIE-MELLON UNIVERSITY
- **SAM.gov UEI:** U3NKNFLNQ613
- **Principal Investigator:** D. Lansing Taylor
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $190,926
- **Award type:** 5
- **Project period:** 1982-07-01 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156307

## Citation

> US National Institutes of Health, RePORTER application 3156307, STRUCTURAL AND CHEMICAL DYNAMICS OF CELL MOVEMENT (5R01AR032461-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156307. Licensed CC0.

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