# MACROPHAGE ANGIOGENESIS IN WOUND HEALING

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 1988 · $162,213

## Abstract

Angiogenesis is an essential component of wound healing regardless if the
wound is traumatic or surgical in origin.  Angiogenesis is also a component
of several pathologic conditions, such as the growth of tumors, diabetic
retinopathy and arthritis, as well as a component of normal growth and
development.  The initiation and regulation of these angiogenic processes
is not fully understood nor likely to be the same in each case.
Macrophages are essential to wound healing and may be the only inflammatory
cells capable of expressing an angiogenesis factor.  This proposal will
concentrate on the functional and structural characterization of an
angiogenesis factor secreted by primary rabbit macrophages and to determine
how that factor relates both functionally and structurally to an
angiogenesis factor derived from human wound fluid.  If there is more than
one angiogenesis factor derived from macrophages or wounds, then the
specific goal of this proposal is to study the nonmitogenic
macrophage/wound fluid angiogenesis factor.

To understand the function of macrophage angiogenesis factor, the response
of capillary endothelial cells to the factor must be studied.  An
angiogenic response can be divided into three phases, production of
proteinases, migration, and proliferation.  Because macrophage angiogenesis
factor is not mitogenic, the major effort of this investigation will focus
on proteinase induction and cell migration.

These studies will provide insights into the role of macrophage mediated
angiogenesis during wound healing.  This information may also be pertinent
to an understanding of angiogenesis that may result from pathologic
inflammation.

## Key facts

- **NIH application ID:** 3156388
- **Project number:** 5R01AR032746-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **SAM.gov UEI:** KMH5K9V7S518
- **Principal Investigator:** MICHAEL J BANDA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $162,213
- **Award type:** 5
- **Project period:** 1983-09-01 → 1991-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156388

## Citation

> US National Institutes of Health, RePORTER application 3156388, MACROPHAGE ANGIOGENESIS IN WOUND HEALING (5R01AR032746-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156388. Licensed CC0.

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