# PATTERNS OF PATHOPHYSIOLOGY IN ARTICULAR DISEASES

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1993 · $246,901

## Abstract

This grant focuses on the microvascular physiology of the synovium both
in human subjects with rheumatoid arthritis and in goats with retroviral
arthritis.  In both species, isotopic tools will be used to determine the
rate of synovial plasma flow, the rate of lymphatic drainage, and the
microvascular permeability to water and to plasma proteins.  Special
attention will be paid to microvascular effects of therapy with steroidal
and nonsteroidal anti-inflammatory drugs.  In particular, it is thought
that plasma flow may be prostaglandin-dependent in some subjects and that
anti-prostaglandin drugs may therefore promote ischemia.  Observations in
patients at rest and during passive and active motion will examine the
impact of exercise on synovial microvascular function.  This aim tests
the hypothesis that gentle motion is more beneficial than rest, but
sustained work is detrimental to circulatory-metabolic homeostasis in
active rheumatoid joints.  A new tool for assessment of synovial
ischemia, magnetic resonance spectroscopy, will be used to evaluate wrist
and hand joints and will be validated by direct intra-articular
measurements of pH and temperature.  The radioisotopic measures will be
used to evaluate both the effects of aging on synovial microvascular
function in control goats and the effects of retroviral arthritis in
infected animals.  These serial studies will follow and quantify the
physiology of both the virus-vulnerable carpal joints and the relatively
virus-resistant hocks.  A course of acute inflammation evolving through
an ischemic phase to "burned out" synovitis is expected.  The
microvascular effects of steroidal and nonsteroidal anti-inflammatory
drugs will be quantified at each stage of this evolution.

## Key facts

- **NIH application ID:** 3156424
- **Project number:** 5R01AR032811-10
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** PETER A SIMKIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $246,901
- **Award type:** 5
- **Project period:** 1983-07-01 → 1995-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156424

## Citation

> US National Institutes of Health, RePORTER application 3156424, PATTERNS OF PATHOPHYSIOLOGY IN ARTICULAR DISEASES (5R01AR032811-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156424. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*