# UV RADIATION AND EPIDERMAL PHOSPHOLIPID METABOLISM

> **NIH NIH R01** · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1989 · $167,366

## Abstract

Solar ultraviolet radiation (UV) is a ubiquitous environmental
agent known to produce numerous effects in human skin including
inflammation, pigmentation, alteration of immune function and
carcinogenesis.  The mechanism by which such radiation evokes
most cutaneous photobiological responses remains poorly defined.
Relatively little attention has been paid to the possible role of
membrane constituents in the mediation of UV-induced skin
changes.  This is in spite of evidence from epidemiological, in vivo
and in vitro studies which suggests that UV damage in skin results
in stimulation of many biologic processes analogous to damage
induced by membrane active agents.  Such agents are known to
act through alterations of membrane phospholipid structure and
function including phospholipase activation, second messenger
induction and lipid derived arachidonic acid metabolite
production.

The overall objective of these proposed studies is to examine the
effect of UV on selected aspects of membrane phospholipid
metabolism in human epidermis.  Specifically, human epidermal
keratinocytes will be utilized in culture as an in vitro model to
assay the effect of UV (UVB -- 280-320 nm and UVA -- 320-400
nm) on phospholipase activation, arachidonate metabolite
production, phosphatidylethanolamine methylation and the
relationship of such membrane alterations to cellular proliferation
and differentiation.

Delineation of the effect of UV on membrane phospholipid
metabolism of human keratinocytes should yield insight into the
role played by such effects on the overall tissue response of
human skin to sunlight.

## Key facts

- **NIH application ID:** 3156613
- **Project number:** 5R01AR033663-06
- **Recipient organization:** COLUMBIA UNIV NEW YORK MORNINGSIDE
- **SAM.gov UEI:** F4N1QNPB95M4
- **Principal Investigator:** VINCENT A DELEO
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $167,366
- **Award type:** 5
- **Project period:** 1984-04-01 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156613

## Citation

> US National Institutes of Health, RePORTER application 3156613, UV RADIATION AND EPIDERMAL PHOSPHOLIPID METABOLISM (5R01AR033663-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156613. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*