# CHARACTERIZATION OF THE IMMUNOREGULATORY CIRCUITS IN MAN

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1987 · $115,255

## Abstract

Recent studies demonstrate that human T cell pool is heterogeneous with
respect to cell surface markers and functional programs.  Moreover, the
cells which comprise the regulatory circuits controlling help and
suppression are still poorly defined despite their importance in a host of
human diseases, including autoimmune and immunodeficiency disorders.  We
believe, given the major recent technical breakthroughs in the definition
of cell surface markers, functional assay systems, and cloning techniques,
that one can develop important new insights into the immunoregulatory
circuit in man.  Furthermore, we have just developed a new set of
monoclonal antibodies which define the T4 suppressor inducer subset
(anti-2H4 antibody) and the T4 helper inducer subset (anti-4B4 antibody)
that will help in the resolution of the heterogeneity of T4 cells.  To
characterize the immunoregulatory circuit in man, we plan to take advantage
of the recently developed primary in vitro anti-DNP antibody forming
system.  This system allows for a precise examination of cell-cell
interactions involved in the generation of supression of anti-DNP antibody
production and for the characterization of the factors released by
immunoregulatory T cells.  Furthermore, we plan to develop KLH specific T
cell clones which have unique regulatory activities.  In addiiton, we plan
to analyze the T cell subsets, functions of isolated cells, and fine
specificity of naturally occurring anti-T cell antibodies in patients with
systemic lupus erythematosus, juvenile rheumatoid arthritis, and Sjogren's
disease.  We believe that the analysis of both normal cells and cells from
patients with autoimmune disease will provide new insights into the
heterogeneity of the diseases and the complexity of the immunoregulatory
circuit.  It is hoped that a better understanding of the regulatory
circuits in man will be critical for both an understanding of the basic
biology of the human lymphocytes and for an understanding of disorders of
lymphocytes which are present in a host of human diseases.  Lastly, it is
believed that rational therapy depends on the precise understanding of the
immunoregulatory circuit.

## Key facts

- **NIH application ID:** 3156629
- **Project number:** 5R01AR033713-03
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** Chikao Morimoto
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $115,255
- **Award type:** 5
- **Project period:** 1985-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156629

## Citation

> US National Institutes of Health, RePORTER application 3156629, CHARACTERIZATION OF THE IMMUNOREGULATORY CIRCUITS IN MAN (5R01AR033713-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156629. Licensed CC0.

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