# EXPERIMENTAL INDUCTION OF SLE BY ALTERED IA

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 1991 · $154,538

## Abstract

The current application proposes to investigate the genetic
control of autoantibody production in experimental and spontaneous
systemic lupus erythematosus in mice.  It will concentrate on two genetic
loci which play a major role in general immunity: immunoglobulin and
major histocompatibility complex.  The proposed work is based on previous
observations that certain alleles at these loci confer particular
susceptibility to autoimmunity.  The specific aims are outlined as
follows:
1.  How does the Igh(b) allotype favor autoantibody production?
     a.   Does the b-allotype effect extend to additional isotypes and
          autoantibody specificities?
     b.   Is b-allotype skewing specific for autoantibodies?
     c.   Does b-allotype skewing of autoantibodies occur in other strain
          combinations?
     d.   Does the allotype effect result from the V-region or C-region?
     e.   Is somatic mutation greater in the b allotype than in the a
          allotype?
     f.   Are there constant region effects?
     g.   Does the light-chain locus also have an effect on autoantibody
          production?
2.   What are the relative roles of I-E version I-A recognition in the
     autoimmune graft-versus-host reaction (GVH)?
     a. Are there quantitative differences in I-A versus I-E recognition?
     b.   Are there differences in fine specificity for ANAs induced by
disparity at I-E versus I-A?
     c.   Are there differences in glomerulonephritis between I-A- and
          I-E-mediated GVH disease?
     d.   How is GVH disease down regulated?
These proposed studies will further the mechanistic understanding of the
genetics of autoimmunity.  Such knowledge will help uncover the basic
immunoregulatory dysfunctions that produce systemic autoimmunity and will
eventually allow the development of rational therapy.

## Key facts

- **NIH application ID:** 3156744
- **Project number:** 2R01AR034156-07
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **SAM.gov UEI:** D3LHU66KBLD5
- **Principal Investigator:** ROBERT A. EISENBERG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $154,538
- **Award type:** 2
- **Project period:** 1984-07-01 → 1996-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156744

## Citation

> US National Institutes of Health, RePORTER application 3156744, EXPERIMENTAL INDUCTION OF SLE BY ALTERED IA (2R01AR034156-07). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156744. Licensed CC0.

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