# PATHOGENETIC FACTORS IN SYSTEMIC LUPUS ERYTHEMATOSUS

> **NIH NIH R01** · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 1988 · $14,250

## Abstract

Genetic factors such as the immunoglobulin (Ig) V region genes and the
major histocompatibility complex (MHC) have been shown to play important
pathogenetic roles in systemic lupus erythematosus (SLE).  Certain SLE
associated autoantibodies are important in some clinical manifestations.
One of them is specific for the Ro/SSA antigen, a RNA-protein complex of
100 KD molecular weight.  The occurrence of anti-Ro/SSA antibodies has
clinical implications.  Because of the availability of two monoclonal
anti-Ro/SSA IgG proteins, hybridoma antibodies has been generated to probe
the V regions of these two Ig's.  Preliminary data indicate that we have
hybridoma antibodies against the private and crossreactive idiotypes of
these proteins.  More monoclonal antibodies which identify various V region
markers of these two monoclonal anti-Ro/SSA Igs and the affinity purified
polyclonal anti-Ro/SSA antibodies from SLE patients will be generated.
These V region markers will be used to determine if a particular V region
is associated with SLE renal disease.  Correlative studies will reveal if
these markers will define subsets of SLE.  Emphasis will be placed on the
anti-Ro/SSA antibodies in the serums of homozygous C2 deficient patient
with an SLE-like syndrome.  A cellular study will be initiated to determine
the numbers of circulating lymphocyte bearing these markers and the
proportions of circulating Ig secreting cells to be positive for these
markers.  An T cell dependent pokeweed mitogen induced Ig synthesis system
and other cellular systems will be used to probe certain aspects of the
regulation of this system.  In a collaborative study, HLA studies will be
performed on our SLE patients and their family members to clarify the role
of MHC and the importance of the interaction between MHC and Ig genes in
the pathogenesis of SLE.  Results of this proposal will lead to new
insights to SLE and related autoimmune disorders.

## Key facts

- **NIH application ID:** 3156755
- **Project number:** 5R01AR034211-05
- **Recipient organization:** OKLAHOMA MEDICAL RESEARCH FOUNDATION
- **SAM.gov UEI:** NGCNCJ1X6XA4
- **Principal Investigator:** Shu Man Fu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $14,250
- **Award type:** 5
- **Project period:** 1984-07-01 → 1988-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3156755

## Citation

> US National Institutes of Health, RePORTER application 3156755, PATHOGENETIC FACTORS IN SYSTEMIC LUPUS ERYTHEMATOSUS (5R01AR034211-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3156755. Licensed CC0.

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